Hmmm...
Yeah, best part of town is the Northern Quarter. (I am biased - living above Bluu!) Goto Cord and Cenro on Tib Street, Fringe Bar on Swan Street (wicked selection of Belgian beers and an excellent jukebox), Bay Horse, Matt and Phreds, Dry, Night and Day etc...
For clubs, you won't beat Sankeys Soap. It's a dirty sweatbox but the music and soundsystem is class! Make sure you go 'cause it will be no-more from June 9th and 10th...sob!!!
Stay away from the Printworks, it's garbage!
Student bars and stuff - Oxford Road. Scallies - Picadilly/Gardens. Deansgate Locks/Castlefield - Wanna Be's(!)
Foodwise - curries and stuff, Rushholme - although mass produced and not very authentic. There's a few little Indian type cafe's in the NQ - supposed to be alot better, not been myself though. Good Sunday lunch - Simple, although the service is poor. Steaks - gotta be Gaucho Grill, Italian - Piccolino's or Croma. Chinese - Yang Sing. Fish - Livebait.
Shopping and stuff - some independent quirky shops in the NQ, posh shops on King Street, high street shops on Market Street and the Arndale centre, then there's Selfridges and Kendals. Try the Trafford Centre too for shopping.
Other clubs to try - Roadhouse, North, Tangled (Phoenix club), err.....not too sure about others, I'm getting old now and don't go anymore...!
Trying to think of other stuff but I've got a hangover and my head hurts! I'll think of more stuff.
Manchester's wicked, you'll love it!